Chiefs vs. Panthers Prediction: Odds, Expert Picks, QB Matchup, Injury Updates, Betting Trends and Stats

The Kansas City Chiefs (9-1) will face the Carolina Panthers (3-7) looking to bounce back from their first loss of the season.

This match is truly a story of two teams, and it’s not just this year. Since the start of the 2018 season (when David Tepper bought the Panthers and Patrick Mahomes entered his first season as the Chiefs’ starting QB), perhaps no team has been more polar opposite. The Chiefs have won three Super Bowls and lead the NFL in wins (84) and winning percentage (.771), while the Panthers have the fewest wins in the NFL (tied with the Jets with 34) during that span.

Mahomes and company could also have a familiar face as there is a chance Isaiah Pacheco will return to the lineup after being sidelined since Week 2 with a broken fibula. If you think Pacheco is coming back with a bang and finding the end zone for the second time this season, it might make sense to sprinkle something on his Anytime TD prop at (-165).

Pacheco isn’t the only running back coming off IR expected to provide a boost to his team’s rushing attack, as Panthers rookie RB Jonathan Brooks (knee) is expected to make his NFL debut. The Texas graduate was the first RB selected in the 2024 NFL Draft but was recovering from a torn ACL he suffered in college. If you think the Panthers will help Brooks get back into contention against tough defenses, it might make sense to take Under for his yards and carries, assuming each is available on DraftKings.

Apart from the games mentioned above, let’s dive into the match and try to sweat it out a couple of times.

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Game details and how to watch Chiefs @ Panthers

· Date: Sunday, November 24, 2024

· Time: 1:00 p.m. Eastern Time

· Website: Bank of America Stadium

· City: Charlotte, North Carolina

· TV/streaming: CBS

NBC Sports Here you will find all the latest news about this match, including live odds, player news, expert analysis and predictions.

Latest Game Betting for Chiefs @ Panthers

Latest odds courtesy of DraftKings:

· Money line: Kansas City Chiefs (-675), Carolina Panthers (+490)

· Spreading: Chiefs -11

· General: 43

The line is at the same level it opened at, with KC leading by 11. However, the total is up 1.5 points to 43 as the Sharpes look for points.

Best bets at NBC Sports Bet

Expert Picks and Predictions for Chiefs @ Panthers

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Our model produces predictions for every moneyline, spread and over/under for every game on the NFL calendar based on data such as past results, player matchups, betting trends and weather forecasts.

Once the model is complete, we place its projection next to the final betting lines in the game to achieve a relative confidence level for each bet.

Here are the best bets our model predicts for Sunday’s game between Kansas City and Carolina:

· Money line: NBC Sports recommends playing on Chiefs on Moneyline

· Spreading: NBC Sports is leaning toward the game on the Chiefs ATS.

· General: NBC Sports recommends playing on the OVER 43 total.

Chiefs @ Panthers Betting Trends & Stats

· Kansas City is 4-5-1 against the spread this season.

· Kansas City is 5-5 in the OVER’s favor this season.

· Carolina is 3-7 against the spread this season.

· Carolina is 7-3 in OVER this season.

· The Chiefs have failed to cover the spread in their last three games against teams with worse records.

· The Chiefs have won 3 games in a row against the Panthers.

Quarterback matchup for Chiefs @ Panthers

· Kansas City: Patrick Mahomes – Under 200 yards passing (196) in 3^district times this season last weekend against the Bills. Cincinnati (151 yards on Sept. 15) and San Francisco (154 yards on Oct. 20) also held veteran QBs under 200 yards this season.

· Caroline: Bryce Young – Enjoying the first two-game winning streak of his career. However 2^ndThe two-year pro threw for just 126 yards in his last start two weeks ago in Munich against the Giants after throwing for just 171 yards against New Orleans the week before.

Panthers Chiefs Injury Update

• KC K Harrison Butker (knee) is on IR and will NOT play in Sunday’s game.
• KC RB Isaiah Pacheco (ankle) is eligible to return from IR but is questionable for Sunday’s game.
• KC DE Charles Omenihu (knee) was limited in Wednesday’s practice and is questionable for Sunday’s game.
• Carolina WR Adam Thielen (hamstring) was limited in Wednesday’s practice and is questionable for Sunday’s game.
• Carolina CB Jaycee Horn (calf) was limited in Wednesday’s practice and is questionable for Sunday’s game.
• Carolina C Xavier Woods (shoulder) was limited in Wednesday’s practice and is questionable for Sunday’s game.
• Carolina RB Jonathan Brooks (knee) is questionable for Sunday’s game.
• Carolina RB Miles Sanders is questionable for Sunday’s game.

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